Trypanocidal Activity of an Organotin Compound (Tri-n-Butyltin Oxide) toward Trypanosoma brucei.
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چکیده
منابع مشابه
Trypanocidal activity of organotin chlorides on Trypanosoma brucei-infected mice.
The organotin compounds dibutyltin (DBTC) and diphenyltin dichlorides (DPTC) were tested for trypanocidal activity on a Trypanosoma brucei-infected mice model. At a dose of 10 mg DBTC and 15 mg DPTC/kg/day for five consecutive days, they cleared the parasites from the peripheral blood of the infected mice. Subinoculation of some healthy mice with the homogenates of liver, spleen, kidney, cerebr...
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background: there are only four drugs for treating african trypanosomiasis, a devastating disease in sub-saharan africa. with slow discovery of better drugs, vaccination is viewed as the best method of control. we previously showed that antibodies to native trypanosoma brucei brucei tubulin inhibit the growth of trypanosomes in culture. here, we aimed to determine the effect of antibodies to ba...
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Bis(tri-n-butyltin) oxide and its various commercial preparations are widely used because of their bactericidal, fungicidal, algicidal, and insecticidal properties (Barnes and Stoner, 1958; Barnes and Stoner, 1959; Elsea and Paynter, 1958; van der Kerk and Luijten, 1954). The commercial preparations of TBTO' are used in industry and in agriculture and as disinfectants in hygiene services (Asche...
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Recently, the World Health Organization approved the nifurtimox-eflornithine combination therapy for the treatment of human African trypanosomiasis, renewing interest in nitroheterocycle therapies for this and associated diseases. In this study, we have synthesized a series of novel 5-nitro-2-furancarboxylamides that show potent trypanocidal activity, ∼1000-fold more potent than nifurtimox agai...
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ژورنال
عنوان ژورنال: Journal of Clinical Biochemistry and Nutrition
سال: 1992
ISSN: 1880-5086,0912-0009
DOI: 10.3164/jcbn.13.81